A Concept for Attribute-Based Authorization on D-Grid Resources

In Germany's D-Grid project numerous Grid communities are working together to provide a common overarching Grid infrastructure. The major aims of D-Grid are the integration of existing Grid deployments and their interoperability. The challenge lies in the heterogeneity of the current implementations: three Grid middleware stacks and different Virtual Organization management approaches have to be embraced to achieve the intended goals. In this article we focus oil the implementation of an attribute-based authorization infrastructure that not only leverages the well-known VO attributes but also campus attributes managed by a Shibboleth federation

Trust Issues in Shibboleth-Enabled Federated Grid Authentication and Authorization Infrastructures Supporting Multiple Grid Middleware

In Germany's D-Grid project numerous Grid communities are working together to develop a common overarching Grid. One major aim of D-Grid is thus to integrate the existing Grid deployments and make them interoperable. The major challenge in this endeavor lies in the heterogeneity of the current implementations: Three Grid middleware and different VO management approaches have to be orchestrated to achieve the intended interoperability. This paper presents some of the findings of the IVOM project regarding VO management technologies. Furthermore, options are discussed for making Shibboleth federations and VO management systems interoperable so that attributes from both sources can be used for authentication and authorization in Grids. Finally two approaches, one using a so called "trust proxy" and one without trust proxying, are presented and support by current Grid middleware is discussed

Clinical and mutation data in 12 patients with the clinical diagnosis of Nager syndrome

Nager syndrome (MIM #154400) is the best-known preaxial acrofacial dysostosis, mainly characterized by craniofacial and preaxial limb anomalies. The craniofacial abnormalities mainly consist of downslanting palpebral fissures, malar hypoplasia, micrognathia, external ear anomalies, and cleft palate. The preaxial limb defects are characterized by radial and thumb hypoplasia or aplasia, duplication of thumbs and proximal radioulnar synostosis. Haploinsufficiency of SF3B4 (MIM *605593), which encodes SAP49, a component of the pre-mRNA spliceosomal complex, has recently been identified as the underlying cause of Nager syndrome. In our study, we performed exome sequencing in two and Sanger sequencing of SF3B4 in further ten previously unreported patients with the clinical diagnosis of Nager syndrome, including one familial case. We identified heterozygous SF3B4 mutations in seven out of twelve patients. Four of the seven mutations were shown to be de novo; in three individuals, DNA of both parents was not available. No familial mutations were discovered. Three mutations were nonsense, three were frameshift mutations and one T > C transition destroyed the translation start signal. In three of four SF3B4 negative families, EFTUD2 was analyzed, but no pathogenic variants were identified. Our results indicate that the SF3B4 gene is mutated in about half of the patients with the clinical diagnosis of Nager syndrome and further support genetic heterogeneity for this condition